Antitussive effects of Musanga cecropioides in animal models

<div>This study investigates the antitussive effects of <em>Musanga cecropioides</em>, a traditional medicinal plant, using animal models. <em>Musanga cecropioides</em> extracts were prepared from the leaves, roots, and root sap, and their effects were evaluated on mucus expectoration and citric acid-induced cough in mice and guinea pigs, respectively. The results indicated that aqueous and methanol extracts of <em>Musanga cecropioides</em> leaves and roots significantly increased mucus secretion and reduced cough frequency, with the highest effectiveness observed in methanol root extract at 100 mg/kg. These findings suggest that <em>Musanga cecropioides</em> possesses promising antitussive properties, supporting its traditional use in treating cough and respiratory ailments. This natural remedy could offer a safer alternative to conventional cough suppressants, warranting further clinical studies to confirm its efficacy and safety in humans.</div>