Formulation And Evaluation Of Anti-Acne Herbal Gel

Herbal medicines have gained global importance due to their medicinal efficacy and cost-effectiveness. Unlike allopathic treatments, plant-based medicines offer better patient compliance with minimal side effects. This study aims to develop and evaluate the anti-acne activity of a hydrogel formulated using water extracts of Rubia cordifolia roots and Azadirachta indica leaves. Rubia cordifolia (Manjistha) is a vital Ayurvedic herb known for its blood purification properties and efficacy in treating skin disorders. It also supports kidney health and exhibits antibacterial, antioxidant, and anti-inflammatory activities beneficial for skin health. Azadirachta indica (Neem) is widely recognized for its antimicrobial and anti-inflammatory properties, making it effective in combating acne-causing bacteria. Physicochemical evaluations of the selected plants confirmed the presence of key phytochemicals, such as alkaloids, glycosides, phenols, and phytosterols. A hydrogel was formulated using Carbopol 934 (1.5% w/w) combined with aqueous extracts of Rubia cordifolia and Azadirachta indica at varying concentrations. In-vitro evaluation revealed that the herbal gel exhibited significant anti-acne activity, showing a superior zone of inhibition against bacterial cultures compared to standard amoxicillin discs. This study concludes that the formulated anti-acne herbal gel is a safe and effective alternative for managing acne vulgaris.