Vasodilation Activity of Saaranai Chooranam in Experimental Rats (In Vivo) In the Management of Raththa Kothippu (Systemic Hypertension)

Siddha Medicine is a one of the most popular medicines in nowadays, it has so many drugs using complete cure of the particular diseases. The trial drug Saaranai chooranam has been mentioned in siddha literature of “Agasthiyar erandayiram – Part-III” for the management of Raththa kothippu (Systemic hypertension). Primary objective of study to evaluate the Vaso dialation activity of Saaranai chooranam in experimental rats. This Observational in vivo study carried out Arulmigu Kalasalingam College of Pharmacy, Tamil Nadu, India. The trial drug contains equal ratio of Saaranai Root and Inthuppu, with adjuvant Ghee or Jagarry. Vasodilation drugs frequently used to treat Systemic Hypertension. A decrease in both diastolic and systolic pressures was observed after Saaranai Chooranam at doses of 200 and 400 mg/kg. The hypotensive response to Saaranai Chooranam could be mediated not only by a central effect but also by a direct effect on the vessels. Effects of Saaranai Chooranam on blood pressure investigated whether it would interfere with the arterial blood pressure of Wistar rats. Rapid and transitory reductions of systolic and diastolic pressures were observed in at doses higher than 100 mg/kg, shows a typical recording of arterial blood pressure before and after treatment of drugs 200 and 400 mg/kg of Saaranai Chooranam. Systolic and diastolic pressures were significantly reduced respectively. Our results suggest that Saaranai Chooranam probably is responsible for the vasodilator activity.