A Comprehensive Review on Liposomes: As Drug Delivery System

Liposome was first discovered by Alec Douglas Bangham, a British hematologist in 1961 at the Babraham Institute, in Cambridge, England. He published his work in 1964. They were discovered when A.D. Bangham and R.W. Horne was testing a new electron microscope in the institute with a dry phospholipid and gram-negative stain. When a self-forming enclosed lipid bi-layer was hydrated, the liposome or lipid vesicle was discovered. Liposome drug delivery systems have played a key role in the development of powerful drugs that have improved therapies Liposome formulations have recently been aimed at reducing toxicity and increasing accumulation at the target site The suppression of rapid liposome clearance by regulating particle size, charge, and surface hydration is one of several new liposome manufacturing methods based on lipid drug interactions and liposome disposition mechanisms. Liposome is a nanoparticle (size-100nm). Nanoscale drug delivery system using liposome as well as nanoparticle. This technology is for "Rational delivery of chemotherapeutic" drug treatment of cancer. Liposome is use as to study the cell membrane and cell organelles. The advantages of liposome formation using microfluidic approach for bulk-mixing approaches are discussed.