Seroepidemiology Of Human Herpesvirus-6 In Different Age Groups In Istanbul

ABSTRACT Objective: This research aimed to elucidate the HHV-6 IgM and HHV-6 IgG antibodies in febrile and healthy individuals using ELISA to determine the distribution rates of HHV-6 antibodies in Istanbul. Method: This research has enrolled 149 individuals (Group 1) admitted to the hospital with fever and had at least two symptoms, such as sore throat, swollen lymph nodes, and increased leukocyte count together with fever, with suspicion of herpes infection and 121 healthy individuals (Group 2) who had no complaints or findings and were admitted to the hospital for routine check-ups—the presence of HHV-6 Ig M and HHV-6 Ig G antibodies in two different groups. Results: According to the study, HHV-6 IgG antibody was detected in 86 (57%), and HHV-6 IgM antibody in 28 (19%) of 149 febrile individuals. HHV-6 IgM antibody was detected in febrile patients. HHV-6 IgG antibody was found in 48% of healthy individuals, and HHV-6 IgM antibody in 6%. HHV-6 IgM was not detected among healthy individuals in the 0-5 month group. The findings were consistent with the HHV-6 IgM and HHV-6 IgG rates reported in the literature. This study shows that HHV-6 was encountered in 48% of healthy individuals. Conclusion: This study's results are consistent with the information in the literature. Based on the data, it was thought that organ transplant recipients and donors should be evaluated for HHV-6 infection and that HHV-6 infection should not be ignored in children admitted to the hospital with fever. Keywords: Human Herpes Viruses (HHV-6), Febrile infectious, Ig M, Ig G, Exanthem subitum.