An update on Targeting Gut Microbiota(GM) for Avoidance of Metabolic dysfunction associated steatohepatitis propagation to Hepatocellular Carcinoma-A Narrative Review.

Abstract Metabolic dysfunction associated steatotic liver disease(namely MAFLD) as well as propagation to Hepatocellular carcinoma(HCC), displayed unique molecular along with immune traits .Such properties get impacted by a plethora of factors inclusive of gut microbiome that crosstalk with liver via the ‘gut - liver axis’. The bidirectional association amongst gut in addition to its microbiota along with liver possesses a critical part in guiding different liver diseases, with microbial metabolites as well as immune reactions possessing a central part in such events .Here we have attempted to update our earlier work with regards to part of gut microbiota(GM) aiding in generation of Metabolic dysfunction associated steatohepatitis( MASH) as well as propagation to HCC, highlighting the recent advancements in diagnostic in addition to therapeutic interventions with regards to use of faecal microbiota transplantation(FMT), probiotics, prebiotics, synbiotics, antibiotics, along with immunotherapy using a plethora of clinical as well as preclinical studies in avoidance of MASH along with propagation to HCC as well as detailed mechanistic modes of such treatments exhaustively inclusive of methodologiesof administration of FMT as well as their approval by Food and Drug Administration(FDA), just for treatment of recurrent Clostridium difficile infection(CDI) ,with future opportunities for therapeutic interventions in a plethora of diseases like obesity, irritable bowel syndrome (IBS), Parkinson’s disease, metabolic syndrome (MetS) type 2 Diabetes mellitus(T2DM), neuropsychiatric disease (NPD) (Autism spectrum disorder (ASD) .More research is needed to overcome the restrictions along with correlated hurdles. Key Words; gut microbiota(GM) ; avoidance of Metabolic dysfunction associated steatohepatitis( MASH); Hepatocellular carcinoma(HCC); immunomodulatory treatments.