Doxycycline induced Urticaria: A Case Report

Doxycycline, a second-generation bacteriostatic antibiotic, is widely used to treat a variety of infections, including those caused by intracellular pathogens. It is effective against both gram-positive and gram-negative bacteria and has potential therapeutic benefits for conditions such as cancer and Alzheimer's disease. However, its use is contraindicated in children below eight years due to possible adverse effects. This case report presents a 28-year-old female patient who developed drug-induced urticaria after being treated with doxycycline for suspected Chikungunya viral arthritis. Following a detailed clinical assessment and laboratory investigations, the patient exhibited symptoms consistent with drug-induced urticaria, including angioedema and severe itching. Management involved the withdrawal of doxycycline, administration of systemic corticosteroids, antihistamines, and supportive care. The patient demonstrated significant improvement, highlighting the importance of recognizing and promptly managing adverse drug reactions (ADRs). This case emphasizes the necessity for on-going monitoring of drug safety and the need for clinical awareness regarding rare but serious ADRs associated with commonly used medications like doxycycline.