Formulation and Evaluation of Nifedipine Transdermal Drug Delivery Systems

This study investigates the development of Nifedipine transdermal patches utilizing varying ratios of Hydroxypropyl Methylcellulose K100 (HPMC K100) and Eudragit L100. The formulations were subjected to rigorous evaluation encompassing physicochemical properties, ex vivo permeation studies, and in vitro iontophoresis assessments. The findings indicate that iontophoresis significantly enhanced drug release compared to the chemical method employing Dimethyl Sulfoxide (DMSO) as a penetration enhancer. The transdermal patches exhibited the requisite flux and suitable mechanical properties, suggesting their potential for effective antihypertensive therapy. The combination of HPMC K100 and Eudragit L100 polymers provides a matrix conducive to controlled drug release. The incorporation of PEG as a plasticizer enhances the mechanical properties of the patches, while DMSO and iontophoresis serve as effective permeation enhancers. The iontophoresis technique offers a non-invasive means to augment drug delivery, potentially improving therapeutic outcomes in hypertensive patients.The study successfully developed Nifedipine transdermal patches with optimal physicochemical properties and enhanced drug release profiles. The iontophoresis-enhanced formulations demonstrated superior performance compared to chemical enhancement methods. These findings underscore the potential of iontophoresis in advancing transdermal drug delivery systems for antihypertensive therapy.