FABRICATION AND OPTIMIZATION OF EMULSOMES CONTAINING TOPICAL GEL OF KETOCONAZOLE

The topical route of administration for a therapeutic drug allows for direct contact with the intended area of the skin. Topical dosage forms such as ointments, creams, and gels are often inadequate in delivering medication to the desired spot, especially in higher concentrations. Advanced drug delivery systems such as liposomes, emulsomes, niosomes, dendrimers, and nanoparticles have the ability to specifically target tissues through the skin layer, offering improved therapeutic options for skin cancer. The findings indicate that when the concentration of the solid core changes and the quantity of lipid content increases, there is a corresponding rise in particle size. Consequently, this leads to an increase in both the PDI (polydispersity index) and the zetapotential action. The results of the dependent variables indicated that the KE4 formulation was chosen to optimize the impact of different surfactants at varying concentrations on the penetration rate or drug entrapment efficiency inside the solid lipid core. The gel basis is required to advance the formulation from emulsomes to emulsomal gel. The gel basis, consisting of a mix of guargum and xanthan gum, was chosen as the optimal concentration of gelling agent. The emulsomes were formulated and converted into an emulsomal gel, which was then assessed using several criteria. The physical assessment of the emulsomal gels revealed a bright yellow color, transparency, and a desirable consistency and smooth texture. The pH of the formulation does not disrupt the physiological balance of the skin. The analysis determined that the KEG4 formulation performed the best across all observations. The drug release perfusion profile and release kinetics of formulations KEG1 to KEG4 exhibited values of n> 0.5, indicating that they followed the Fickian diffusion and supercase II transport mechanism.