ALLERGY - DEVELOPMENT OF ALLERGIC DISEASES

Allergic diseases such as anaphylaxis, hay fever, eczema and asthma affect about 25% of people in developed countries today. In people with allergies, chronic or repeated exposure to allergens, which are typically harmless substances commonly found in the environment, leads to chronic allergic inflammation. This, in turn, leads to long-term changes in the structure of the affected organs and significant abnormalities in their activity. Therefore, it is important to understand the characteristics and consequences of acute and chronic allergic inflammation, particularly how cells contribute to the multiple features of this discordant pattern of immunological reactivity. The notion that antibodies that are supposed to protect against disease are also responsible for disease seems absurd at first. The term "allergy" was coined by Clemens von Pirket in 1906 to refer to the unusual tendency of some individuals to develop signs and symptoms of reactivity or "hypersensitivity reactions" when exposed to certain substances). Although the above statement refers to the 2 causes of serum sickness, allergic diseases (also called atopic diseases, from the Greek atopos , meaning out of place) are also associated with allergen-specific IgE production and allergen exposure. . - Specific populations of T-cells, both of which are generally reactive with otherwise innocuous environmental agents. In the developed world, these diseases are becoming more and more common and include allergic rhinitis (also called hay fever), atopic dermatitis (also called eczema), allergic (or atopic) asthma, and certain foods. Some people develop a potentially fatal systemic allergic reaction called anaphylaxis within seconds or minutes of exposure to an allergen.