Formulation And Characterization of Sustain Release Drug Delivery of Glycopyrrolate and Formoterol for The Treatment of Chronic Obstructive Pulmonary Disease (COPD)

The objective of the current work was to formulate and evaluate sustained release matrix tablets of Glycopyrrolate and Formoterol. The tablet was prepared by wet granulation Method using Xanthan gum, Karaya gum and HPMC K100M. Compatibility studies between Drug and Excipients showed that DS showed no significant change. The FT-IR studies showed that there is no interaction between the drug and excipients, as all peaks corresponding to different functional groups of pure drug were present in the drug-excipient mixture. All the formulations and their mixture showed acceptable flow properties like angle of repose, bulk density, tapped density. Prepared tablets were found to be good in terms of post compression parameters and also passed out quality control evaluation parameters as per I.P limits. In vitro dissolution study revealed F4 as the most emperical formulation showing Glycopyrrolate release of 99.75% in 12 hours and Formoterol release of 98.45% in 12 hours. Thus based on the overall graphs it was found that the respective formulations F4 Glycopyrrolate were followed Peppas release kinetics mechanism whereas Formoterol was followed first orders Release Kinetics..