Novel antagonists reveal the mechanism of PXR inhibition

The pregnane X receptor (PXR) is a key regulator of metabolism, but the mechanisms underlying its antagonism remain unclear. Garcia-Maldonado et al. reported potentnew antagonists and their cocrystal structures, revealing molecular determinants of PXR antagonism and paving the way for developing antagonists as therapeutics and preventing undesirable PXR activation.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2024-10-16
DOI
https://doi.org/10.5281/zenodo.14056165
Primary Topic
Pharmacogenetics and Drug Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

Novel antagonists reveal the mechanism of PXR inhibition

Zenodo (CERN European Organization for Nuclear Research)
Pharmacogenetics and Drug Metabolism
article

Novel antagonists reveal the mechanism of PXR inhibition

article en

Abstract

The pregnane X receptor (PXR) is a key regulator of metabolism, but the mechanisms underlying its antagonism remain unclear. Garcia-Maldonado et al. reported potentnew antagonists and their cocrystal structures, revealing molecular determinants of PXR antagonism and paving the way for developing antagonists as therapeutics and preventing undesirable PXR activation.

Zenodo (CERN European Organization for Nuclear Research)
Charles University (CZ), University Hospital Hradec Králové (CZ), University of Hradec Králové (CZ)
Openalex Percentile: Top 58%
Pharmacogenetics and Drug Metabolism
DOIOpen Access PDFOpenAlex
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Novel antagonists reveal the mechanism of PXR inhibition · Zenodo (CERN European Organization for Nuclear Research) (2024) | TGRS Research Map | TGRS