Preparation And Evaluation Oral Buccal Patches Of Ambroxol Hydrochoride As Mucolytic

This study aims to develop and evaluate oral buccal patches containing Ambroxol Hydrochloride (AH) for its mucolytic effects. Buccal patches offer advantages such as bypassing first-pass metabolism, sustained drug release, and improved patient compliance. Buccal patches were prepared using the solvent casting method with various polymers including Hydroxypropyl methylcellulose (HPMC), methyl alcohol, citric acid, etc were incorporated as plasticizers to enhance flexibility. The formulated buccal patches demonstrated uniform thickness and weight, satisfactory folding endurance, and appropriate surface pH, indicating good compatibility with the buccal environment. The swelling index and moisture content were within acceptable ranges, ensuring patch integrity and stability. In vitro drug release studies showed a sustained release profile of Ambroxol Hydrochloride over an extended period, suggesting effective prolonged drug delivery. The bioadhesive strength was found to be adequate, ensuring prolonged adhesion to the buccal mucosa for effective drug absorption.