Comprehensive Documentation and Critiques on Pashanabhedadi Kwatha: Exploring its Potential in Chronic Kidney Disease (CKD)

ABSTRACT : In Ayurveda, the treatment of Chronic Kidney Disease (CKD) is approached through a holistic lens, where the focus lies not just on alleviating symptoms but also on restoring balance to the body’s intricate systems. Pashanabhedadi Kwatha, a revered polyherbal formulation, exemplifies this Ayurvedic approach by combining a unique blend of herbs (such as Pashanabheda, Yastimadhu, Vasa, Gokshura, Eranda, Aragwadha phala majja, Pippali, Ela, Shilajit, Souvarchala lavana, and Mishri), each chosen for its specific role in supporting kidney health, also known for their diuretic, anti-inflammatory, and detoxifying properties. When combined, they work synergistically to enhance renal function, regulate fluid balance, and reduce inflammation, which are crucial factors in managing CKD. In Ayurveda, kidney dysfunction is often attributed to imbalances in the doshas, accumulation of ama and disturbances in agni and srotas. Pashanabhedadi Kwatha is formulated to address these imbalances, with its herbs targeting specific physiological processes that support renal and metabolic health. The present study aims to evaluate the effects of Pashanabhedadi Kwatha on CKD through the lens of Ayurvedic principles like Rasa Panchaka, and to explore its influence on doshic imbalances, ama, agni, srotas, and the specific phytochemical constituents responsible for its therapeutic benefits. By reviewing both classical and modern literature, this study seeks to shed light on the potential mechanisms behind its beneficial effects in CKD and offer insights into its clinical applications.