Solubility Modification of Phytochemicals via Pharmaceutical Cocrystal

Pharmaceutical cocrystal is an approach to physicochemical and mechanical properties of a drug substance the cocrystal are composed of conformer and API which are mainly used for solubility and dissolution mechanical properties and stability of drug. this review will provide information about what is cocrystal, how they are prepared, what is the advantages behind the pharmaceutical cocrystal preparation, the whole cocrystal development pathway in which all the steps involved in the cocrystal formation from selection of API to the after preparation scale up process are given. the concept of multidrug cocrystal are given, then the different method of crystallization the main focused on this review on herbal cocrystal it provide information about herbal cocrystal. Case studies of varies herbal cocrystal have been discussed. The chart of herbal drug along with their conformer and the method of preparation and application of cocrystal. we can achieve successful drug delivery through co-crystallization. the pharmaceutical industry will beneficial through successful development of co-crystallization of herbal drug substance.