Synthesis, Characterisation, Biological Evaluation and Analogizing the Antimycotic Activity of 2,4,5-Triphenylimidazole Derivatives

Microwave Assisted Synthesis (MWAS) technique which significantly lowers the chemical waste and reaction time. MWAS has been utilized to synthesize the 2,4,5-Triphenylimidazole by Debus-Radziszewski imidazole synthesis. From the literature survey, 2,4,5-Triphenylimidazole derivatives were synthesized under MWAS using Benzil, Ammonium Acetate and Aldehydes like Benzaldehyde, 4-chlorobenzaldehyde, 4-Nitrobenzaldehyde and 4-Methoxbenzaldehyde by Condensation reaction. Compounds were synthesized in the presence of Glacial acetic acid as a catalyst in solvent-free condition. The purity of the compound was determined by Thin Layer Chromatography (TLC). The synthesized compounds were screened using FT-IR. All synthesized compounds were evaluated and analogized for anti-mycotic activity.