Virosomes, Hybrid Vehicles For Efficient And Safe Drug Delivery With New Applications

Virosomes are viral envelopes that can be packaged as vaccines and carriers for cellular transfer of various macromolecules. Since virosomes are biologically active, they are non-toxic and non-autoimmune. Attempts have been made to use them as antibiotics or as adjuncts and delivery systems for drugs and organic compounds for medical purposes. Studies have shown that the virosome can carry a variety of biological molecules such as nucleic acids, peptides, proteins and small organic molecules. Virosome is a revolutionary hybrid drug delivery system that combines the advantages of viral and non-viral carriers. Abstract: Virosomes are spreadable envelopes that can be used as vaccines and carriers for the cellular delivery of various macromolecules. Since virosomes are bioactive, they are non-toxic and non-autoimmune. Attempts have been made to use them as antibiotics, food additives and delivery systems for drugs and organic compounds for medical purposes. Studies have shown that virosomes can carry a variety of biomolecules such as nucleic acids, peptides, proteins and small molecules. Virosome is a revolutionary hybrid drug delivery system that combines the advantages of viral and non-viral carriers. Therefore, this review provides a new perspective on the production, materials and application of virosome-based nanovaccines in viral diseases, especially for SARS-CoV-2 vaccine discovery. To increase the efficiency of gene transfer by introducing molecules directly into cells, virosomes have been created by combining liposomes with viral envelope proteins. Currently, a lot of research has been done on new methods of vaccine delivery, including microparticles, liposomes and nanoparticles, among other things for infectious diseases. In contrast to conventional methods of vaccine production, virosome-based vaccines represent the next generation of vaccines due to the balance between potency and tolerance in terms of stimulation prevent. The liposome surface is modified with antibodies and ligands that are recognized by specific cell types to improve tissue localization. Liposomes and fungal protein have been combined to form virosomes, which deliver molecules directly into the cell, thereby improving the efficiency of gene transfer