Trabeculectomy with Mitomycin and Ologen Implant and Their PostOperative Outcomes

Objective: A comparative study on trabeculectomy with MMC versus an Ologen implant in POAG patients of eastern India. Methods: A retrospective study conducted at SCB Medical College and Hospital, Cuttack, included 40 patients aged 18-80 years with POAG who were treated between January 2021 and June 2022. Group 1 (n=20) was treated with trabeculectomy with MMC, and Group 2 (n=20) received Olo implants. Postoperative bleb morphology was assessed by IBAGS, and complications and additional interventions were recorded. Chi-square and Fisher’s exact tests were used for statistical analysis. Result: At early postoperative stages within up to 1 mo postoperatively, groups that received Olo displayed significant differences in bleb height. Implants had also degraded after 180 days. In comparison between both groups, the study results indicated higher vascularity of blebs carrying MMCs at 6-month intervals compared with those carried on implants of Olo as given by the p-values less than 0.01. Complications occurring without showing significant group-related differences were anterior chamber reaction and hyphema. More thin blebs and choroidal detachment were found on MMC-treated eyes. Conclusion: Olo implants achieved a higher early postoperative bleb height but had a greater incidence of vascular blebs at 6 months. MMC treatment was accompanied by avascular blebs but had a higher incidence of thin blebs. Both treatments were safety equivalent. Further large-scale randomized studies are recommended to make more extensive clinical outcome reports and to establish long-term efficacy.