Formulation, Development and Invitro Evaluation of Nicorandil Extended Release Tablets

The nicorandil extended release tablets are prepared by wet granulation method using differentpolymers in varying combinations.. Compatability studies were carried out and found that drugs andexcipients are compatible with each other.post compression parameters were carried out found to bewithin the limits. Tablet blends were prepared and micromeritic studies were carried out are found to bewithin the limits. The dissolution data of all formulations reveals that as combination of Compritol,Carbopol showed increases the percentage drug release was found to be increased Formulation (F8)containing combination of Compritol, Carbopol934P shows that the 98.5% drug release was found in24hrs .