Evaluation Of Solanum Melongena Linn. Fruit Extract On Myonectin Expression- An In Vitro Approach

Myonectin is a significant endogenous protein which was discovered in 2011 and many research works were done on this protein. It has tremendous physiological effects in human body. Myonectin secreted by skeletal muscle and it regulate many metabolic processes in human body, and its low concentrations may play a role in the pathophysiology of Metabolic syndrome, by favouring the accumulation of abdominal fat and the consequent development of IR. Myonectin is also known as C1q/TNF-related protein isoform 15 (CTRP15), whose gene is located on locus2q37.3. This myokine was discovered very recently by Seldin and coworkers. According to the authors, myonectin expression is stimulated by two main factors: exercise and nutrients. Fasting circulating myonectin levels were shown to be low and to increase 2 hours after the intake of glucose or lipid Ethnopharmacological evidence shows that Solanum melongena Linn. Fruits possesses various pharmacological effects including anti-oxidant, anti-diabetic, antihypertensive, anti – hyperlipidaemic, and anti-obesity etc. Myonectin expression was quantified by RT-qPCR method. Total phenol content in solanum melongena extract was estimated by folin-ciocalteu method and total flavonoid content was estimated by aluminium chloride colorimetric method. Purpose of this study was to evaluated the effect of solanum melongena Linn. fruits extract effect on myonectin expression by using RAW 267.4 cell line. The invitro result showed that Solanum melongena Linn. Fruits extract modulate the myonectin gene expression in vitro and this result helps the future researchers. In future this positive effect of Solanum melongena Linn. Fruits shall test for clinical efficacy for the treatment of myonectin deficiencies.