Review 1: "Genomic Epidemiology Uncovers the Timing and Origin of the Emergence of Mpox in Humans"

The article presents a significant investigation into the emergence and transmission dynamics of the mpoxvirus (MPXV) in Nigeria, particularly in the context of the recent global outbreak. By generating and analyzing112 MPXV genomes collected from 2021 to 2023, the study provides essential insights into the virus's origin,evolutionary mechanisms, and implications for public health. It identifies key aspects of the transmissionlineage, pinpointing its emergence around July 2014 and its persistence in Southern Nigeria. This review willhighlight the study’s strengths, including its methodological rigor and relevance to public health, while alsoidentifying opportunities for improvement, particularly in data interpretation and broader implications forsurveillance and response strategies.