CORRELATION OF SERUM CHLORIDE LEVELS WITH RESPIRATORY SUPPORT REQUIREMENTS AND CRITICAL CARE OUTCOMES IN RESPIRATORY FAILURE

Background and Aims: Respiratory failure, a critical condition disrupting gas exchange, requires tailored interventions for effective management. While serum chloride is essential for acid-base balance, its prognostic role in respiratory failure remains under-investigated. This study aimed to evaluate serum chloride as a biomarker for assessing respiratory support needs and predicting outcomes in critical care. Methods: This observational longitudinal study, conducted at the Heritage Institute of Medical Sciences over 18 months, included 126 patients with respiratory failure. Patients were monitored for serum chloride levels at 0, 2, 6, 12, 24, 36, and 48 hours, with comparisons made across respiratory support modes. Statistical analyses included ANOVA and logistic regression, focusing on the relationship between chloride fluctuations and patient outcomes. Ethical approval and patient consent were obtained. Results: Significant differences in serum chloride levels were observed over time (p < 0.001). At key intervals (0 and 36 hours), chloride levels demonstrated a correlation with outcomes, as indicated by ANOVA and logistic regression. Patients with abnormal chloride levels required extended ICU stays, aligning with outcomes seen in critically ill patients. Conclusion: Serum chloride monitoring showed potential as a prognostic tool in respiratory failure management, with variations in chloride levels aiding in outcome prediction and guiding timely interventions. Regular chloride assessment could enhance clinical decision-making, optimizing patient management in critical care settings.