Formulation And Evaluation of Sustained-Released Ivabradine Hydrochloride Tablets Using Natural Gums

This study investigates the application of natural gums as release-modifying agents in the formulation of sustained-release matrix tablets using Ivabradine Hydrochloride as a model drug. Tablets were prepared via direct compression, using gums such as xanthan, guar, and karaya in varying ratios. Evaluations included pre-compression and post-compression parameters, in-vitro drug release, swelling index, and stability studies. The formulation with xanthan gum at a 1:2 drug-to-polymer ratio exhibited optimal drug release of 98% over 24 hours, following zero-order kinetics. Swelling studies revealed superior hydration, ensuring consistent drug diffusion. Natural gums proved to be effective as matrix formers for sustained drug delivery, with potential implications for patient compliance and cost-effective drug delivery systems.