Identification of MAPK1 Inhibitors from Blumea oxyodonta and Cardiospermum halicacabum for Colorectal Cancer

Abstract: Colorectal cancer is significant health concern worldwide. Mitogen-activated protein kinase 1 (MAPK1) is a critical therapeutic target for this malignancy. Natural compounds have potency for different type of cancers due to their diverse structures. Compounds selected for this study were taken from Blumea oxyodonta and Cardiospermum halicacabum. Computational docking analysis revealed promising binding affinities of some of these compounds to MAPK1, suggesting their potential as lead molecules for developing novel therapeutic interventions against colorectal cancer.