Drug Repurposing of Pantoprazole for Its Anticancer Activity Focusing on Its Anti-Angiogenic Potential

Drug repurposing is an emerging strategy used to identify new targets for drugs that are already been in clinical use for a different disease. It is both a cost effective and time saving alternative since the pharmacological, safety and toxicity profiles are already established. The proton pump inhibitor Pantoprazole has shown anticancer activity in few studies done on cancer cell lines and also revealed that it has got a role in the anti-angiogenesis mechanism. To establish the anticancer profile, MTT assay has been done. It showed that Pantoprazole has got cytotoxic activity on cancer cell lines. The preliminary evaluation of cytotoxicity was done on mung beans and evaluated for its sprouting response. The inhibition of germination also revealed the cytotoxic potential of the drug. Chorioallantoic membrane assay was done to evaluate the angiogenic potential of the drug. Pantoprazole disrupted the vascularization in the fertilized egg in a concentration of 50 microgram/ml.