Sustain Release Herbal Tablet Containing Ocimum Sanctum and Glycyrrhiza Glabra for The Treatment of Cough

Coughing is the protective mechanism of the body. In the critical condition like cold it leads to form phlegm in the respiratory system. So, it needs to be cured as early as possible. Some pharmaceutical formulations used to treat coughing were syrups and solutions. These preparations had several disadvantages like bioavailability, dosing frequency and stability problems. To overcome these problems matrix tablet was developed. Matrix tablet consists of polymers which retards the release of the API and gave a prolonged action. Due to the controlled release of the drug, dosing frequency reduced thrice as compared to the liquid dosage forms like syrups. The API used in the formulation was herbal in nature so it had the advantage of having fewer side effects. Reduction in dosing frequency had also helped in increasing the patient compliance. The extracts were loaded in the formulation by mixing it with excipients like polymers, diluents, fillers, lubricants, etc. Direct compression technique was used to formulate the matrix tablets. Pre and post compressional parameters were determined with respect to the standards. The formulations passed all the physical and pharmaceutical parameters. The results of precompressional parameters were good to passable. The results of the post-compressional parameters were satisfactory. The in-vitro release of the formulation was from 18 to 20hrs. Dissolution profile of the drug showed zero order release.