HIV and Syphilis Coinfection, Epidemiological and Clinical Profile at the Simbaya Institut of Neurology, Conakry

Introduction: HIV and Syphilis co-infection is a simultaneous infection by the human immunodeficiency virus and by treponema pallidum that can lead to clinical polymorphism.  Material and Methods: We conducted a retrospective descriptive study over a period of 2 years (from January 1, 2022 to December 31, 2023 on patients received in outpatient consultation at the Simbaya Institute of Neurology (INS). We included all patients received in outpatient consultation at the INS for neurological symptoms related to HIV and syphilis co- infection confirmed by biology. The epidemiological and clinical variables were evaluated for each patient.  Results: We found 121 cases of co-infection out of 1420 patients (8.5%), with a mean age of 51.8±15.1 years, and a sex ratio of 0.95. Housewives were the most represented in the socio-professional stratum (35.5%). The majority of patients came from urban areas (73.6%). Fever (100%), motor deficit (90.9%), memory disorders (74.4) and vigilance disorders (61.9%) were the dominant neurological signs.  Conclusion: It emerges from this study that HIV and Syphilis co- infection is of increasing frequency at the Simbaya Institute of Neurology with a predominance of young subjects. Housewives were the most represented and mostly living in urban areas, neurological manifestations are often late during a syphilitic infection unlike HIV and Syphilis co-infection.