Lifting the curse from high-dimensional data: Automated projection pursuit clustering for the variety of biological data modalities

Contents: Supplementary_Data_Pairwise_Projections_PBMCs.zip: 10 principal components for the PMBC dataset plotted against each other in a pairwise manner with labeled clusters Covid_dataset.zip: PHA: flow cytometry data for Covid patients and healthy controls PHA_IDs: cluster labels for the Covid dataset in PHA folder README_COVID-samples: link to information about samples in Covid dataset RAG-KO immune dataset.zip: ground truth immune cell clustering from GFP+Wild-type and RAG-KO mice at five different proportions. (RAG-KO mice are deficient in generating lymphoid lineages, while GFP+ mice represent a healthy immune system with constitutive GFP expression in all immune cell lineages, which allows for easy and accurate detection of immune cell populations by flow cytometry, simplifying the identification and quantitation of cell lineages)

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2025-02-15
DOI
https://doi.org/10.5281/zenodo.14874269
Primary Topic
Single-cell and spatial transcriptomics
Type
article
Field-Weighted Citation Impact
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article

Lifting the curse from high-dimensional data: Automated projection pursuit clustering for the variety of biological data modalities

Zenodo (CERN European Organization for Nuclear Research)
Single-cell and spatial transcriptomics
article

Lifting the curse from high-dimensional data: Automated projection pursuit clustering for the variety of biological data modalities

article en

Abstract

Contents: Supplementary_Data_Pairwise_Projections_PBMCs.zip: 10 principal components for the PMBC dataset plotted against each other in a pairwise manner with labeled clusters Covid_dataset.zip: PHA: flow cytometry data for Covid patients and healthy controls PHA_IDs: cluster labels for the Covid dataset in PHA folder README_COVID-samples: link to information about samples in Covid dataset RAG-KO immune dataset.zip: ground truth immune cell clustering from GFP+Wild-type and RAG-KO mice at five different proportions. (RAG-KO mice are deficient in generating lymphoid lineages, while GFP+ mice represent a healthy immune system with constitutive GFP expression in all immune cell lineages, which allows for easy and accurate detection of immune cell populations by flow cytometry, simplifying the identification and quantitation of cell lineages)

Zenodo (CERN European Organization for Nuclear Research)
Emory University (US)
Openalex Percentile: Top 60%
Single-cell and spatial transcriptomics
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