A Study on the Correlation of Brain Natriuretic Peptide (BNP) and Troponin I in Acute Coronary Syndrome and Its Relation to Clinical Outcome

Background: Acute coronary syndrome (ACS) is a life-threatening condition resultingfrom reduced blood flow to the myocardium, which can lead to ischemia andinfarction. Biomarkers such as brain natriuretic peptide (BNP) and troponin I (Trop I)play key roles in the diagnosis and prognosis of ACS. Investigating the correlationbetween these biomarkers and clinical outcomes may enhance risk stratification.Objectives: To determine the correlation between BNP and troponin I levels in ACSpatients and assess their relationship with clinical outcomes such as left ventricular(LV) dysfunction, arrhythmias, and mortality. Methods: A prospective observationalstudy was conducted on 75 patients diagnosed with ACS at a tertiary care hospital.BNP and troponin I levels were measured on days 1 and 3 of hospitalization, andclinical outcomes were documented during the hospital stay and after 1 month. Themain outcomes included reinfarction, cardiogenic shock, ventricular arrhythmias, andmortality. Results: Of the 75 patients, 58.67% were male, with a mean age of 59.25years (±11.15). Major risk factors were hypertension (54.67%), diabetes mellitus(49.33%), and dyslipidemia (13.33%). Patients with BNP levels >600 pg/mL had asignificantly higher incidence of complications (90.9%) compared to those with lowerBNP levels. Similarly, 91.66% of patients with troponin I >20000 ng/L developedcomplications such as LV dysfunction and arrhythmias. Conclusion: Elevated BNPand troponin I levels are significantly correlated with adverse clinical outcomes in ACSpatients. BNP and troponin I can serve as valuable prognostic markers for identifyinghigh-risk patients