INFLUENCE OF NATURAL BIOENHANCER QUERCETIN ON PERMEABILITY CHARACTERISTICS OF GRANISETRON ACROSS GOAT INTESTINAL MEMBRANE MODEL

The purpose of the present study was to explore the effect of presence of bioenhancer quercetin on membrane permeability of poorly permeable Granisetron HCl, across goat intestinal membrane using Franz diffusion cell. The effect of quercetin was investigated upon co- administration of different concentrations (2, 6, 10, 14 and 18mg) of quercetin and upon pre- treatment at different time periods (30, 60 and 120 min) on goat intestinal permeability of Granisetron HCl in phosphate buffer pH 7.4. Data obtained from permeability studies were used to calculate percentage cumulative drug release (% CDR), apparent permeability (Papp), flux (J) and enhancement ratio (ER). The pretreatment studies with quercetin for 1 and 2 hours culminated in a notable enhancement in the permeability of Granisetron HCl. The % CDR values after 60 min (55.70%) and 120 min (49.13%) of pre-treatment are higher than control drug (41.78%). This implies that a 60-minute pre-treatment shows a more optimal effect. The study revealed that co-administration of the different concentrations of quercetin has detrimental effect on the membrane permeability of drug. However, upon pre-treatment at different periods, it improves the permeability of Granisetron HCl.