EFFECT OF PROBIOTICS ON PATIENTS WITH INSULIN RESISTANCE

In the last few years, the study of intestinal microflora in patients with prediabetes, obesity and insulin resistance has been of particular importance. Obesity and its associated diseases are still one of the leading causes of disability and death. The human gastrointestinal tract is a complex ecosystem consisting of host cells, intestinal microflora and nutrients. The aim of our study was to study the microbiome of patients with insulin resistance and to observe the change in Homa index based on its correction using probiotics. Based on our research, we can conclude that the long-term inclusion of probiotics in the treatment of patients with insulin resistance for 12 weeks with the following combination: Lactobacillus rhamnosus-1.0x10*9, Lactobacillus casei-1.0x10*9, Lactobacillus acidophilus-1.0x10*9 , Bifidobacterium bifidum- 1.0x10*9) 6 caps. per day, significantly reduces dyspeptic symptoms, at the expense of loss of appetite and weight loss, reduces body mass index. It also helps to reduce the waist circumference, which can probably be explained by the burning of fat deposits deposited by probiotics. In patients with insulin resistance, taking probiotics for a long time - at least 12 weeks, reduces the degree of insulin resistance and improves the quality of life.