Study Antioxidant of Synthesized Nickel (II) Phthalocyanine: Characterization and Biological Activity

Abstract Nickel (II) phthalocyanine is a group of coordination compounds belonging to the phthalocyanines class, a macrocyclic complexes compound. It comprises a central-nickel (Ni²⁺) ion coordinated to a large, planar ligand organization composed of four isoindole units linked by nitrogen-atom, forming a conjugated system similar to porphyrins. The complex of phthalocyanine was produced through the reaction of p - cyanobenzamide with nickel ion (Ni²⁺) and analysis by FTIR, UV-visible and 1HNMR spectroscopy test. The DPPH “radical-scavenging test” was using to test the antioxidant properties with varying concentrations of Nickel (II) phthalocyanine complex in methanol solution. The results confirmed the successful synthesis of high-quality “Nickel phthalocyanine complex” and confirmed by spectroscopic examinations. The complex demonstrated significant “antioxidant activity” achieving an 85% scavenging effect on the (DPPH radical) at a concentration of (25 μg). The conclusion of this study appeal that synthesized Nickel (II) phthalocyanine shows promising antioxidant properties in optimum concentration (25 μg). Keywords: DPPH; Nickel ΙΙ; Nickel (II) phthalocyanine; p-cyanobenzamide