Advances in bioavailability enhancement technique for poorly aqueous soluble drugs- comprehensive review

The limited water solubility of pharmacologically active molecules poses a constraint on their pharmacological potential. Despite the non-negotiable solubility parameter, various strategies are employed to augment bioavailability. Solubility and bioavailability are pivotal for optimal therapeutic effects at the target site. Overcoming the challenge of enhancing drug bioavailability and solubility is a significant focus in pharmaceutical formulations. In order to enhance the solubility of low water-soluble medicinal products, by means of a variety of techniques including particle size reduction, nanonization, pH correction, solid dispersion, complexation, cosolvency and hydrotropy. The objective is to elucidate techniques for effective absorption and heightened bioavailability.