Inosine boosts infant antiviral immunity.

Early antibiotic exposure disrupts the gut microbiota, impairing newborn antiviral immunity. Stevens et al. uncover that inosine, a metabolite produced by gut bacteria, restores the function of antiviral T cells by modulating gene regulation, boosting lung immune defenses against respiratory viruses.

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Publication Details

Journal
Open Access CRIS of the University of Bern
Published
2025-08-13
DOI
https://doi.org/10.48620/90630
Primary Topic
Pediatric health and respiratory diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

Inosine boosts infant antiviral immunity.

Open Access CRIS of the University of Bern
Pediatric health and respiratory diseases
article

Inosine boosts infant antiviral immunity.

article en

Abstract

Early antibiotic exposure disrupts the gut microbiota, impairing newborn antiviral immunity. Stevens et al. uncover that inosine, a metabolite produced by gut bacteria, restores the function of antiviral T cells by modulating gene regulation, boosting lung immune defenses against respiratory viruses.

Open Access CRIS of the University of Bern
GP Forschungsgruppe (DE)
Good health and well-being
Openalex Percentile: Top 39%
Pediatric health and respiratory diseases
DOIOpen Access PDFOpenAlex
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Inosine boosts infant antiviral immunity. · Open Access CRIS of the University of Bern (2025) | TGRS Research Map | TGRS