Predictive value of serum reactive oxygen species levels in end-stage renal disease occurrence among elderly patients with chronic kidney disease

[Objective] To analyze the predictive value of serum reactive oxygen species (ROS) levels in end-stage renal disease occurrence among elderly patients with chronic kidney disease. [Methods] A total of 174 chronic kidney disease patients who received treatment at the First Affiliated Hospital of Xinjiang Medical University from January 2020 to December 2023 were selected as the research subjects. Patients were divided into a progressive group and a non progressive group based on whether they had progressed to end-stage renal disease, with 49 cases in the progressive group and 125 cases in the non progressive group. Baseline dates were collected using a commercialized enzyme-linked immunosorbent assay kit to detect serum ROS levels in patients. Multivariate logistic regression models were used to analyze the correlation between serum ROS levels and chronic kidney disease progression, and ROC curves were used to analyze the predictive efficacy of serum ROS levels for the progression of chronic kidney disease to end-stage renal disease. [Results] Age, male proportion, systolic blood pressure, and 24-hour urinary protein quantification and sumer ROS levels in the progressive group were higher than those in the non progressive group (P<0.05), while estimated glomerular filtration rate was lower than that in the non progressive group (P<0.05). Multivariate logistic regression lines showed that serum ROS was an independent risk factor for progression to end-stage renal disease in elderly patients with chronic kidney disease after adjusting for confounders (P<0.05). ROC curves showed that serum ROS cut-off value for predicting progression of chronic kidney disease was 14.61 ng/mL, predicted AUC was 0.81 (95% CI: 0.75 to 0.88), sensitivity was 84.8%, and specificity was 70.2%. [Conclusion] Serum ROS levels are significantly associated with the risk of progression to end-stage renal disease in elderly patients with chronic kidney disease and have some predictive value.