"IN SILICO ANALYSIS OF ANTIMICROBIAL ACTIVITY IN NOVEL PYRIMIDINOL DERIVATIVES"

The burgeoning of resistance to antimicrobial drugs is a key the ample defence behind continued research into new compounds. Ciprofloxacin (CPFX) was chosen as standard compound, a virtual screening refinement was appliance to examine the interaction between the compound and its potential targets. Compounds that showed stronger interactions with the target than Ciprofloxacin (CPFX) were selected for further development. The in - silico analysis of these compounds suggested they had drug-like properties and demonstrated good bioactivity and pharmacokinetic properties. Fifteen derivatives of Pyrazol- pyrimidine were synthesized and confirmed by using molecular docking techniques.[1]The process of molecular docking, which involves the arrangement of new Pyrazol- pyrimidine derivatives drawn by Chem Draw 3D (version 16.0) was constitute at the subatomic level by using conventional bond lengths and angles.