Progress in the diagnosis and treatment of mycosis fungoides with large cell transformation

Mycosis fungoides is a non-Hodgkin lymphoma originating from skin-resident memory helper T cells, representing the most common subtype of cutaneous T-cell lymphoma. Large cell transformation is a unique form of primary cutaneous T-cell lymphoma with unclear etiology and pathogenesis. Clinical manifestations and auxiliary examinations lack specificity. Whether patients need aggressive treatment is controversial. This article systematically reviews the etiology, pathogenesis, clinical manifestations, diagnosis, treatment, and prognosis of mycosis fungoides with large cell transformation, offering insights for its diagnosis and management.