Why does weight regain occur after weight loss?

Obesity， as a global health issue， presents significant challenges in its treatment and management， particularly the phenomenon of weight regain. This not only undermines the effectiveness of weight loss efforts but may also have further impacts on the physical and mental health of patients. This article delves into the issue of weight regain during the treatment of obesity， analyzing its definition， prevalence， and health implications. It elucidates the biological mechanisms of weight regain from aspects such as the body weight set-point theory， metabolic adaptation， immune cell phenotypic changes， lipid metabolism， and appetite regulation. A comprehensive management strategy is proposed， including lifestyle adjustments， continuous pharmacological treatment， surgical intervention， and multidisciplinary collaboration， aiming to achieve long-term weight control in obese patients. The study emphasizes the continuity and individualization of weight management， providing scientific guidance for clinical practice.