SERUM HSP 90 LEVELS OF CHRONIC HEPATITIS B PATIENTS ARE SUBSTANTIALLY CORRELATED WITH HBV DNA VIRAL LOAD

The highly conserved molecules that make up the mammalian HSP90 family of proteins are engaged in a wide range of cellular functions. HSP90 and its co-chaperones regulate vital physiological processes as apoptosis, hormone signaling, and cell cycle regulation. The aim of this research are to examine the critical function that HSP90 plays in chronic HBV patients and to determine the association between this protein type and other immunological and biochemical markers as well as the HBV DNA factor. 88 chronic HBV patients were included in the trial, which ran from June to December 2015. The levels of ALT, AST, AFP, HBsAg, HBeAg, and anti-HBsAb were measured. The results showed a significant correlation between HSP90 [mean of 4.909±10.4839] with the titer of HBV DNA in the serum [190943784.21±180568331.64] in the chronic HBV patients at (P=0.002) involved in the study [P= or <0.01]. The relationship between HSP90 and other serological and biochemical parameters are shown no significant correlation.