C5 and CD14 inhibition after multiple trauma in pigs contributes to an immunologically balanced miRNA pattern at the fracture site and reduces pro-inflammatory and pro-fibrotic systemic miRNA responses

Objectives: Multiple trauma can exert severe immunological responses at sites of injury and in the systemic circulation. Modulating the post-traumatic immune response may therefore offer therapeutic potential in the treatment of multiply traumatized patients. A novel combined inhibition therapy targeting [for full text, please go to the a.m. URL]