Effects of Chronic Exposure for Imidacloprid and Nano-Imidacloprid on some biochemical and hematological parameters in male rats

Although considered a good alternative to organophosphate pesticides, there are reports indicating adverse effects of neonicotinoid insecticides on reproduction. The present work was designed to determine the chronic effects of orally administered for treated with 20 mg/kg/b.w. of imidacloprid pesticides and treated with 20 mg/kg/b.w. of nano-imidacloprid on biochemical blood profile in male rats for a duration of 60 d. Result: the exposure caused a significant decline in red blood cells (RBCs) and hemoglobin (H.b.) in all treated groups compared with the control, while causing an increase in blood platelets (PLT) and white blood cells (WBCs) in all rats treated as compared with the control rats. Furthermore, oxidative stress parameters showed a highly significant (P≤0.05) increase in malondialdehyde (MDA) after 60 d of exposure and a decline in reduced glutathione (GSH) and catalase activity (CAT). The imidacloprid pesticides and nano-imidacloprid lead to an increase the amount of total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) in treated groups, while the high-density lipoprotein (HDL) level is reduced in treated groups as compared with the control group.