A Study of Platelet Parameters and Their Correlation with Different Clinical Manifestations of Tuberculosis: A Pre- and Post-Treatment Analysis

Introduction: Recent studies show that platelets play a pivotal role inthe pathogenesis of chronic diseases. However, the exact variation ofplatelet parameters in different manifestations of tuberculosis has notyet been studied effectively.Objectives: To explore the variation of platelet count, Mean PlateletVolume (MPV), and Platelet Distribution Width (PDW) in tuberculosisand the changes in indices after 2 months of initiation of antituberculartreatmentMaterials and Methods: This was a cross sectional study where thehaematological reports of 150 patients attending the Departmentof Pulmonary Medicine were studied. The platelet indices of thesepatients were followed up 2 months after initiation of treatment andcompared with the initial data.Results: Out of the 150 treatment naïve patients, 97 were of pulmonarytuberculosis with no drug resistance. Their initial mean platelet countwas 1,07,000/mm3 , which increased to 2,52,000 after 2 months. Theinitial mean PDW was 21.2 reduced to 17.7 after two months oftreatment. The initial MPV was 12 fL, which became 11.2 fL aftertwo months. In the remaining 53 patients including those with drugresistance, tubercular pleural effusion, and military tuberculosis, theinitial mean platelet count, PDW, and MPV were 95000/mm3, 25.2 and 7.1 fL that transformed to a mean of 1,18,000/mm3 , 19.7 and 7.7 fL respectively, 2 months after initiating treatment.Conclusion: This study indicates a tendency towards thrombocytopaeniain tuberculosis patients and an increase in PDW. However followingthe initiation of treatment, the platelet count increased rapidly witha decrease in other indices.   How to cite this article:Gangopadhyay G, Siddiqui B, Baneen U, GautamS, Ali A M D. A Study of Platelet Parametersand Their Correlation with Different ClinicalManifestations of Tuberculosis: A Pre- andPost-Treatment Analysis. J Commun Dis.2024;56(4):105-109. DOI: https://doi.org/10.24321/0019.5138.202479