Analysis of perceived stress, quality of life, and influencing factors in patients with Crohn’s disease and perianal lesions

[Objectives] To explore the correlation between perceived stress and quality of life as well as their influencing factors in patients with Crohn’s disease (CD) accompanied by perianal lesions. [Methods] A convenience sampling method was employed to select 303 CD patients with perianal lesions who were admitted to The Sixth Affiliated Hospital of Sun Yat-sen University from August to December 2023 as the survey subjects. Self-designed general information questionnaires, the Perceived Stress Scale (PSS), and the Inflammatory Bowel Disease Quality of Life Scale (IBDQ) were utilized for analysis. The Perceived Stress Scale was adopted to assess the current stress levels of patients. At the same time, the IBDQ was used to evaluate the quality of life. [Results] There were statistically significant differences in the quality of life scores among CD patients with perianal lesions regarding different working statuses, different per capita monthly household incomes, the presence or absence of nutritional risks, and the use or non-use of biologics (P<0.05). The total score of perceived stress was (24.1±9.0), and the total score of quality of life was (170.3±33.9). Pearson correlation analysis demonstrated a negative correlation between perceived stress and quality of life in these patients (r＝-0.584, P<0.01). Multiple linear regression analysis results indicated that the use of biologics, per capita monthly household income, the presence of nutritional risks, and the total score of perceived stress were influencing factors for the quality of life of CD patients with perianal lesions. [Conclusion] In clinical nursing, attention should be paid to the perceived stress levels and quality of life of CD patients with perianal lesions. Intervention measures should be formulated to assist patients in reducing stress levels, thereby effectively improving their quality of life.