Acetylation modification and chronic obstructive pulmonary disease

The main features of chronic obstructive pulmonary disease include chronic airway inflammation, persistent airflow limitation, progressive dyspnea, and impaired lung function. Acetylation is one of the most common post-translational modifications of proteins, which plays an important role in the pathogenesis of chronic obstructive pulmonary disease, such as oxidative stress, inflammatory reaction, and airway remodeling, by regulating gene expression, cell signaling, and protein function. Therefore, exploring the regulatory mechanism of acetylating modification in chronic obstructive pulmonary disease can not only deeply understand the pathophysiological mechanism of the disease, but also provide a theoretical basis for the development of new treatment strategies.