Anti-oncogenic activity of novel compounds and reference drugs <i>in vitro</i>. KASUMI-1 cells were treated with a series of FLT3/TAF1 compounds and cell viability was determined using a CellTiter Glo assay, while cell toxicity was determined using a

(A) Compound activity in KASUMI-1 cells at 0.001-30 µM (n = 1). (B) IC<sub>50</sub> values of FLT3/TAF1 inhibitors. Each dose-response curve represents an independent experiment. Dots represent individual data points and the gray area represents the 95% confidence interval for each curve. Both single FLT3 inhibitors (3i-1244, 3i-1245, 3i-1247) and dual FLT3/TAF1 inhibitors (3i-1103, 3i-1246, 3i-1248) were used for experiments. (PDF)

Publication Details

Journal
Figshare
Published
2025-03-28
DOI
https://doi.org/10.1371/journal.pone.0320443.s008
Primary Topic
Cell death mechanisms and regulation
Type
article
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article

Anti-oncogenic activity of novel compounds and reference drugs in vitro. KASUMI-1 cells were treated with a series of FLT3/TAF1 compounds and cell viability was determined using a CellTiter Glo assay, while cell toxicity was determined using a

Figshare
Cell death mechanisms and regulation
article

Anti-oncogenic activity of novel compounds and reference drugs in vitro. KASUMI-1 cells were treated with a series of FLT3/TAF1 compounds and cell viability was determined using a CellTiter Glo assay, while cell toxicity was determined using a

article en

Abstract

(A) Compound activity in KASUMI-1 cells at 0.001-30 µM (n = 1). (B) IC<sub>50</sub> values of FLT3/TAF1 inhibitors. Each dose-response curve represents an independent experiment. Dots represent individual data points and the gray area represents the 95% confidence interval for each curve. Both single FLT3 inhibitors (3i-1244, 3i-1245, 3i-1247) and dual FLT3/TAF1 inhibitors (3i-1103, 3i-1246, 3i-1248) were used for experiments. (PDF)

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Cell death mechanisms and regulation
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Anti-oncogenic activity of novel compounds and reference drugs <i>in vitro</i>. KASUMI-1 cells were treated with a series of FLT3/TAF1 compounds and cell viability was determined using a CellTiter Glo assay, while cell toxicity was determined using a · Figshare (2025) | TGRS Research Map | TGRS