Effects of KpACE deficiency on virulence in a pneumonia model using both female and male mice.

<p>(A) Survival rates of mice (6 female and 4 male) infected by <i>K</i>. <i>pneumoniae</i> variants. Mouse survival rates were monitored 7 days post intranasal infection with 2,000 CFU of various ATCC43816 strains. The Gehan-Breslow-Wilcoxon test was performed to compare the survival rates. (B-D) Bacterial colonization in different organs of infected mice (3 female and 3 male). Bacterial burdens in lungs (B), livers (C), and spleens (D) were determined 48 h post intranasal inoculation. Each dot represents one mouse. An unpaired <i>t</i>-test was performed to determine the statistical significance.</p> <p>(PDF)</p>