Showing how cell area changes over time when exposed to various concentrations of the antibiotics.

Initially, all bacteria have the same morphology as they are introduced to the pads with antibiotics. As time progresses, many antibiotics cause a significant change in morphology for some concentrations. Generally, the largest differences are apparent after 2 hours of growth. Each line represents the mean area per cell for a given antibiotic concentration, and the shaded area represents the standard deviation with data originating from three or more repeats. Darker colours correspond to higher antibiotic concentration, and data points are binned to the nearest 30 minutes. The plots for <i>E.coli</i> with ciprofloxacin, mecillinam and chloramphenicol are also presented in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1012924#ppat.1012924.g004" target="_blank">Fig 4</a> and are included here for completeness. (PDF)