The association of polygenic risk scores with individual cancer in the CKB cohort.

Participants in the CKB cohort were divided into five equal groups according to their polygenic risk scores, and the HRs for each group were compared with those in quintile 1 (HR 1.0 [ref]) of the polygenic risk score with the adjustment of age, sex (if applicable), region, and the top 10 principal components. The error bars represent 95% CIs and their centers represent the HRs. PRS, polygenic risk score; CKB, China Kadoorie Biobank; HR, hazard ratio; CI, confidence interval. (DOCX)