<i>Tacstd2</i> expression in cystic epithelium.

<p>(A) Dotplot of marker genes supporting cell type assignments in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.g003" target="_blank">Fig 3E</a>. Markers according to Chen et al. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.ref019" target="_blank">19</a>]. Dot radius represents percent of cells in cluster expressing the gene. Opacity scale indicates average gene expression level within expressing cells. Row normalized. (B) UMAP from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.g003" target="_blank">Fig 3E</a> with cell type assignments as labeled by Ransick et al. [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.ref021" target="_blank">21</a>]. (C) Dotplot of marker genes used to annotate <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011510#pgen.1011510.s011" target="_blank">S3B Fig</a>. Dot radius represents percent of cells in cluster expressing the gene. Opacity scale indicates average gene expression level within expressing cells. Row normalized. (D) DotPlot visualizing the localization of CICs to the murine kidney cell atlas. Dot radius represents percent of cells in cluster expressing the gene. Opacity scale indicates average gene expression level within expressing cells. Row normalized. Main bars (far left) represent increased expression (red) or decreased expression (blue) in our data; sub bars (left) represent epithelial restricted expression (magenta), broad expression (green), and stromal/indeterminate (gray). Black arrow points to <i>Tacstd2</i>, an epithelial cyst initiating candidate. Blue arrow points to PKD2.</p> <p>(PDF)</p>