Impact of functional iKIR on 17 significantly protective <i>DRB1-DQB1</i> haplotypes.

<p>iKIR score effect on HLA class II mediated protection was assessed for 17 significantly protective phased haplotypes in our cohort by stratifying the cohort into individuals with a high iKIR score and individuals with a low iKIR score and the protective effect of the haplotype calculated separately in the two strata. Regression coefficients, 95% confidence intervals, p-values and counts in each stratum are reported for each haplotype. The protective effect of class II haplotypes is enhanced in the group of individuals with a low iKIR score (an iKIR score equal to 1.75 or lower) with the exception of <i>DRB1*07</i>:<i>01-DQB1*03</i>:<i>03</i>. The odds of seeing this difference by chance were assessed by permutation test for each haplotype (3×10<sup>7</sup> permutations). Wald test p-values are reported for the unstratified analysis (Group = Whole cohort).</p> <p>(PDF)</p>